A REVIEW OF TRAMADOL (RETARD)

Opioid activity is due to the two lower affinity binding with the mum or dad compound and better affinity binding on the O-demethylated metabolite M1 to μ-opioid receptors. In animal models, M1 is as much as 6 instances far more strong than tramadol in making analgesia and two hundred instances a lot more strong in μ-opioid binding.Clinical Issue